Nicotine polacrilex and nicotine salt represent two distinct approaches to nicotine delivery. Nicotine polacrilex, found in nicotine gums and lozenges, utilizes an ion-exchange resin to gradually release nicotine when chewed or dissolved. This controlled release helps individuals manage cravings and withdrawal symptoms during smoking cessation efforts. In contrast, nicotine salt, commonly used in vaping e-liquids, involves chemically modifying nicotine with an organic acid to create a smoother vaping experience and allow for higher nicotine concentrations. This modification enhances the absorption of nicotine, delivering a more potent and satisfying hit for users. Both methods offer effective nicotine delivery options, catering to the diverse needs and preferences of individuals seeking alternatives to smoking.